How To Reduce Your Pace Of Aging: Understanding Longevity and Biological Aging with Ryan Smith

Chronologically, you get 1 year older every year. But how old are you getting biologically?

In order to optimize longevity, you need to understand biological aging.

With all the different longevity and biological aging tests, it can be difficult to understand where to start.

Fortunately, we got Ryan Smith from Tru Diagnostic on today’s episode to guide you on all things longevity and biological aging.

In this episode, Ryan highlights the different biological aging tests and which one is the most accurate.

He also gives helpful tips on how to reduce your pace of aging, and how that’s important for your overall lifespan.

Ryan Smith is the founder of TruDiagnostic, which has created the largest private epigenetic database in the world with over 25,000 patients tested. From this dataset, they have created many new algorithms to interpret methylation data including algorithms to predict inflammatory markers, disease diagnosis, telomere length, aging pace, immune cell subsets, cellular replication, and more.


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• SelfDecode:

• The Joe Cohen Show:

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Ryan Smith:

• Website:



(0:00) – Intro

(1:48) – Where does epigenetics fall into aging biomarkers?

(21:52) – Different responses in anti-aging protocols

(39:44) – epigenetic test vs. lab tests

(48:42) – How to use biological age tests to improve health

(55:09) – Pace of aging

(1:05:15) – Immune system age

(1:09:11) – How to reduce the pace of aging

(1:26:39) – How many supplements does Ryan take per day?

(1:35:42) – Metformin and rapamycin on aging

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