Siim Land: How To Lower Cholesterol & Improve Longevity | Episode 03

Is high cholesterol really bad for you? In this episode, Joe and Siim Land discuss what causes high cholesterol, which biomarkers to track for longevity, and the biggest mistake people make when trying to lose weight.

Siim shares one surprising mineral that can help lower cholesterol and talks about how intermittent fasting helps his mental & physical performance. Then, Siim and Joe discuss a top supplement for longevity and healthspan.

Siim Land is a renowned public speaker and expert in biohacking, health optimization, and overall performance optimization. He is also the author of Metabolic Autophagy and The Immunity Fix with Dr. James Dinicolantonio. 

This interview is not intended as medical advice.

– Check out SelfDecode

– Join Joe’s online community

– Follow Joe on Instagram


(0:00) – Introduction

(0:41) – Why Siim Got Into Biohacking

(2:35) – What markers should you measure for longevity?

(8:28) – Taking blood tests every year to track improvements

(10:40) – The top supplement to improve longevity

(13:21) – Cholesterol in the biohacking world

(14:23) – Intermittent fasting, fats, and lowering cholesterol

(17:04) – Zinc and Copper ratio

(18:27) – Does lower T3 contribute to high cholesterol?

(19:37) – One supplement with high evidence of increasing lifespan

(20:36) – What Siim tracks on a regular basis

(22:43) – Siim’s HRV numbers

(23:54) – How Siim improves mental performance

(26:25) – How Siim improves physical performance

(30:09) – The biggest mistake people make with fat loss

(34:55) – Genetics affect on portion control in diets

(36:40) – How often is Siim physically active per day?

(38:05) – How you process carbs differently based on your body composition

(40:34) – Sleephacking tips from Siim Land

(45:54) – Improving your immunity

Listen & subscribe on your favorite
podcast platform

Listen to these next

February 16, 2024

Master The 3 Pillars Of Immune Health

Get an in-depth overview of the components of the immune system, learn how to identify when they’re compromised, and get insights on how to support them to prepare your body for illness. Joe discusses the importance of focusing on immune support before illness occurs, diving deep into the roles of mitochondria, extracellular matrix, and inflammation, […]

Listen Now
February 9, 2024

Exploring Rapamycin, Longevity and Healthspan with Dr. Matt Kaeberlein

In this episode, Dr. Matt Kaeberlein, CEO of OptiSpan and co-director of the Dog Aging Project, and Joe explore the fascinating realm of rapamycin and its implications for longevity and healthspan. Dr. Kaeberlein delves into the biological mechanisms underlying rapamycin’s effects, the best way to take it, and its impact on immune system processes. Gain […]

Listen Now
February 2, 2024

A Practical Guide to Lab Tests for Optimal Health

Dive into the world of lab testing and unlock the secrets to optimal health. In this episode, Joe sheds light on the crucial role lab tests play in understanding our health, cautioning against the limitations of standard tests often offered by conventional medicine. Delve deep into the realm of comprehensive testing as Joe shares his […]

Listen Now
January 26, 2024

Energy, Mental Clarity and NAD: Biohacking with James Schmachtenberger

Join Joe in a conversation with successful biohacker and CEO of Neurohacker Collective, James Schmachtenberger. James shares his two-decade-long journey with biohacking, focusing on improved energy, cognitive function and how NAD changed his life. Learn about utilizing research, software solutions like genetics and lab tests, lifestyle changes, and supplementation for optimizing your health. ————— Socials […]

Listen Now

Join My Community
of Health Optimizers

People who are serious about their health are a different breed of people. We try weird stuff. We don’t blindly trust what “they” tell us. People usually think we’re a little crazy.


Maybe we are, but we’re also going to live the longest ( #longevity), so eventually us “crazy” biohackers will be the only ones left.

Sign up for my list to get the latest podcast episodes, best biohacking tips & all my (often unpopular) opinions