The Science Of Mood, Mitochondria, and Brain Energy w/ Siobhan Mitchell

In this episode of The Joe Cohen Show, Joe sits down with Chief Scientific Officer of MitoQ, Dr. Siobhan Mitchell. Siobhan shares her impressive academic and industry experience and knowledge to explore mood, cognitive function, and mitochondrial health.

Her industry experience includes giants like Unilever, Nestle, PepsiCo, and Noom, where she worked on the fascinating effects of nutrition on mood and cognition.

Siobhan and Joe do a deep dive into the serotonin-mood connection, helping us understand the genetic risk factors for depression and anxiety. Siobhan also shines a light on the underestimated significance of brain energy to mood and how mitochondrial strength plays a key role in this context.

Siobhan also demystifies oxidative stress misconceptions and explains the impact of targeted antioxidants such as COQ10 and MitoQ.

Finally, we delve into the ‘Ozempic’ effect of fiber on our gut health and how it could suppress your appetite naturally. Siobhan illustrates her firm belief that understanding the food we consume can prevent numerous diseases – truly, food is our medicine.

Explore these topics and much more as we discuss the human brain, mood, and the pioneering research in the field of mitochondrial health.


Socials & Websites:

• SelfDecode:

• The Joe Cohen Show:

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Siobhan Mitchell:

• Website:



(0:00) – Intro

(1:31) – Serotonin & Mood

(12:56) – Brain Energy and mood

(16:53) – Oxidative Stress & Muscle Growth

(23:14) – Supplements that reach the brain

(28:51) – CBT, physiology, and mood

(32:00) – What are isoflavones?

(38:43) – Difference between SSRIs and Tryptophan or 5HTP

(50:04) – Brain energy and mitochondria health

(56:15) – Fiber, Butyrate, and the Ozempic Effect

(1:02:53) – Favorite probiotics

(1:04:14) – Deep dive into fish oils

(1:09:16) – Siobhan’s supplement stack

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