The Science Of Mood, Mitochondria, and Brain Energy w/ Siobhan Mitchell

In this episode of The Joe Cohen Show, Joe sits down with Chief Scientific Officer of MitoQ, Dr. Siobhan Mitchell. Siobhan shares her impressive academic and industry experience and knowledge to explore mood, cognitive function, and mitochondrial health.

Her industry experience includes giants like Unilever, Nestle, PepsiCo, and Noom, where she worked on the fascinating effects of nutrition on mood and cognition.

Siobhan and Joe do a deep dive into the serotonin-mood connection, helping us understand the genetic risk factors for depression and anxiety. Siobhan also shines a light on the underestimated significance of brain energy to mood and how mitochondrial strength plays a key role in this context.

Siobhan also demystifies oxidative stress misconceptions and explains the impact of targeted antioxidants such as COQ10 and MitoQ.

Finally, we delve into the ‘Ozempic’ effect of fiber on our gut health and how it could suppress your appetite naturally. Siobhan illustrates her firm belief that understanding the food we consume can prevent numerous diseases – truly, food is our medicine.

Explore these topics and much more as we discuss the human brain, mood, and the pioneering research in the field of mitochondrial health.


Socials & Websites:

• SelfDecode:

• The Joe Cohen Show:

• Instagram:

• TikTok:

• Twitter:

Siobhan Mitchell:

• Website:



(0:00) – Intro

(1:31) – Serotonin & Mood

(12:56) – Brain Energy and mood

(16:53) – Oxidative Stress & Muscle Growth

(23:14) – Supplements that reach the brain

(28:51) – CBT, physiology, and mood

(32:00) – What are isoflavones?

(38:43) – Difference between SSRIs and Tryptophan or 5HTP

(50:04) – Brain energy and mitochondria health

(56:15) – Fiber, Butyrate, and the Ozempic Effect

(1:02:53) – Favorite probiotics

(1:04:14) – Deep dive into fish oils

(1:09:16) – Siobhan’s supplement stack

Listen & subscribe on your favorite
podcast platform

Listen to these next

June 14, 2024

Biohacking, Fitness and Longevity with Jean Fallacara

In this episode, Joe speaks with Jean Fallacara, a multifaceted entrepreneur, neuroscientist, and calisthenics enthusiast. Jean shares insights on how he maintains peak performance through biohacking, focusing on supplements, exercise routines, and meditation practices. Joe and Jean dive deep into the realms of precision health, genetic testing, and maintaining a balanced, enjoyable lifestyle while pursuing […]

Listen Now
June 7, 2024

How Proline Can Make You A Hypochondriac | Supplement Deep Dive

In this episode, Joe dives into the complex world of proline supplementation. He discusses the impacts proline has on collagen synthesis, aiming for improved skin health, enhanced wound healing, and better exercise recovery. However, the journey took an unexpected turn as Joe explains the biomechanics behind why he experienced several side effects such as anxiety, […]

Listen Now
May 31, 2024

Can This Outperform Caffeine for Better Focus? | Supplement Deep Dive

Join Joe as he takes a closer look at saffron, a spice revered not just for its flavor but for its impressive health benefits. In this deep dive, Joe explores how saffron could potentially outshine caffeine in enhancing mental clarity and focus. This episode goes in-depth on how saffron impacts various aspects of health, from […]

Listen Now
May 24, 2024

Decrease Your Heavy Metals by 75% With This Supplement | Supplement Deep Dive

Join Joe as he delves into his journey with MSM (Methyl Sulfonyl Methane) supplementation, a key to detoxing the body and enhancing recovery. In this episode, Joe discusses: – The Impact of Heavy Metals on Health: Understanding the dangers of heavy metals and the importance of detoxing them from our bodies. – MSM as a […]

Listen Now

Join My Community
of Health Optimizers

People who are serious about their health are a different breed of people. We try weird stuff. We don’t blindly trust what “they” tell us. People usually think we’re a little crazy.


Maybe we are, but we’re also going to live the longest ( #longevity), so eventually us “crazy” biohackers will be the only ones left.

Sign up for my list to get the latest podcast episodes, best biohacking tips & all my (often unpopular) opinions